25th PAGE Meeting

Lisboa - Portugal
7-10 June, 2016

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Abstracts (21)

I-05Miro Eigenmann

PBPK modeling approach to study the impact of lymph flow on the biodistribution of therapeutic antibodies

Wednesday 10:20-11:40

I-15Saskia Fuhrmann

Generic PBPK model to predict preclinical and clinical PK of antibodies

Wednesday 10:20-11:40

I-25Ignacio Gonzalez-Garcia

Assessment of in vitro dissolution specifications based on an IVIVC and in vivo bioequivalence criteria

Wednesday 10:20-11:40

I-36Nina Hanke

Physiologically-based Pharmacokinetic Modeling of Rifampin Drug-Drug Interactions with Midazolam and Digoxin

Wednesday 10:20-11:40

I-45Xiao Hu

Population pharmacokinetic analysis of fampridine in Japanese patients with multiple sclerosis in a Phase 3 study

Wednesday 10:20-11:40

I-53Masoud Jamei

Time variation in the fractional contribution of an enzyme to elimination of a victim drug can explain differences in DDI susceptibility following single and multiple dosing

Wednesday 10:20-11:40

I-56Jong Bong Lee

Predicted versus experimental permeability data for incorporation into GastroPlus™ for modelling and simulations

Wednesday 10:20-11:40

II-15

Prediction of food effect in the Chinese population using a PBPK model developed in a Caucasian population

Wednesday 15:10-16:30

II-31Hannah Britz

Physiologically-Based Pharmacokinetic (PBPK) Modeling of the Dronedarone Drug-Drug Interaction with Digoxin

Wednesday 15:10-16:30

II-49Yumi Cleary

Physiologically –based pharmacokinetic (PBPK) and population PK (PPK) modeling for basimglurant – assessment of predicted variability by the PBPK model and its utility

Wednesday 15:10-16:30

II-57André Dallmann

Validation of a Population Physiologically-Based Pharmacokinetic Model for Pregnant Women

Wednesday 15:10-16:30

II-60Miné De Kock

Pharmacokinetics of Sulfadoxine and Pyrimethamine for intermittent preventive treatment of malaria during Pregnancy and after delivery.

Wednesday 15:10-16:30

II-62Mailys De Sousa Mendes

A physiologically based pharmacokinetic model for a drug metabolized by several CYP450 during pregnancy

Wednesday 15:10-16:30

III-08

A Novel Mechanistic Approach to Predict the Steady State Volume of Distribution (Vss) using the Fick-Nernst-Planck Equation

Thursday 10:05-11:30

III-29Morris Muliaditan

Prediction of the exposure of anti-tuberculosis drugs in lung tissue: implications for dose selection

Thursday 10:05-11:30

III-37Andrés Olivares-Morales

Combining population with physiologically-based pharmacokinetic (PBPK) models for oral drug absorption: Predicting the segmental bioavailability differences of R-oxybutynin and its main metabolite using a middle out approach.

Thursday 10:05-11:30

III-63

Development of a PBPK approach to predict the pharmacokinetics in patients with sepsis

Thursday 10:05-11:30

IV-26Donato Teutonico

Whole-body PBPK/PD modelling of ciprofloxacin and its anti-bacterial activity

Thursday 14:40-16:00

IV-30Huybrecht T'jollyn

Pharmacokinetics of galantamine in plasma and brain for different intranasal formulations: an experimental in vivo study

Thursday 14:40-16:00

IV-38

Assessment of DDI potential of ruxolitinib (INC424), a dual substrate of CYP3A4 and CYP2C9, using a verified PBPK model to support submissions to Health Authorities

Thursday 14:40-16:00

IV-53Ulrika Wählby Hamrén

Pharmacokinetics of the inhaled selective glucocorticoid receptor modulator AZD5423 following inhalation using different devices

Thursday 14:40-16:00