Abstracts - PAGE Meeting (Population Approach Group Europe)

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Abstracts (28)

B-03Dyfrig Hughes

Quantitative benefit-risk analysis based on linked PKPD and health outcome modelling

Wednesday 09:00-09:40

B-06Jonathan French

Can methods based on existing models really aid decision making in non-small-cell lung cancer (NSCLC) trials?

Wednesday 09:40-10:00

B-07Jonas Bech Møller

Optimizing clinical diabetes drug development – what is the recipe?

Wednesday 10:00-10:20

B-09Jim Riviere

Food safety: the intersection of pharmacometrics and veterinary medicine

Wednesday 11:45-12:25

B-11

Two models for the control of sea lice infections using chemical treatments and biological control on farmed salmon populations

Wednesday 13:50-14:20

B-12Dan Haydon

From Epidemic to Elimination: Density-Vague Transmission and the Design of Mass Dog Vaccination Programs

Wednesday 14:20-14:50

B-14Wojciech Krzyzanski

Physiologically Structured Population Model of Intracellular Hepatitis C Virus Dynamics

Wednesday 16:20-16:40

B-15Martin Bergstrand

Modeling of the concentration-effect relationship for piperaquine in preventive treatment of malaria

Wednesday 16:40-17:00

B-16Matt Hutmacher

A Visual Predictive Check for the Evaluation of the Hazard Function in Time-to-Event Analyses

Wednesday 17:00-17:20

B-17

Non-inferiority clinical trials: a multivariate test for multivariate PD

Wednesday 17:20-17:40

C-01Abhishek Gulati

Simplification of a multi-scale systems coagulation model with an application to modelling PKPD data

Thursday 08:45-09:10

C-19Nelleke Snelder

Mechanism-based PKPD modeling of cardiovascular effects in conscious rats – an application to fingolimod

Thursday 09:10-09:35

C-20Nadia Terranova

Mathematical models of tumor growth inhibition in xenograft mice after administration of anticancer agents given in combination

Thursday 09:35-10:00

C-23

Application of a mechanistic, systems model of lipoprotein metabolism and kinetics to target selection and biomarker identification in the reverse cholesterol transport (RCT) pathway

Thursday 11:35-11:55

C-24Rollo Hoare

A Novel Mechanistic Model for CD4 Lymphocyte Reconstitution Following Paediatric Haematopoietic Stem Cell Transplantation

Thursday 11:55-12:15

C-25Huub Jan Kleijn

Utilization of Tracer Kinetic Data in Endogenous Pathway Modeling: Example from Alzheimer’s Disease

Thursday 12:15-12:35

C-27Justin Wilkins

Reproducible pharmacometrics

Thursday 14:05-14:35

C-28Nick Holford

MDL – The DDMoRe Modelling Description Language

Thursday 14:35-14:55

C-30Vittal Shivva

Identifiability of Population Pharmacokinetic-Pharmacodynamic Models

Thursday 16:20-16:40

C-31Leonid Gibiansky

Methods to Detect Non-Compliance and Minimize its Impact on Population PK Parameter Estimates

Thursday 16:40-17:00

C-32Julie Bertrand

Penalized regression implementation within the SAEM algorithm to advance high-throughput personalized drug therapy

Thursday 17:00-17:20

D-01Shelby Wilson

Modeling the synergism between the anti-angiogenic drug sunitinib and irinotecan in xenografted mice

Friday 09:00-09:20

D-35S. Y. Amy Cheung

Using a model based approach to inform dose escalation in a Ph I Study by combining emerging clinical and prior preclinical information: an example in oncology

Friday 09:20-09:40

D-36Sonya Chapman

Tumour growth inhibition modelling and prediction of overall survival in patients with metastatic breast cancer treated with paclitaxel alone or in combination with gemcitabine

Friday 09:40-10:00

D-39Chuanpu Hu

Latent variable indirect response modeling of continuous and categorical clinical endpoints

Friday 10:50-11:10

D-40Anne-Gaelle Dosne

Application of Sampling Importance Resampling to estimate parameter uncertainty distributions

Friday 11:10-11:30

D-41Hoai-Thu Thai

Bootstrap methods for estimating uncertainty of parameters in mixed-effects models

Friday 11:30-11:50

D-42

New methods for complex models defined by a large number of ODEs. Application to a Glucose/Insulin model

Friday 11:50-12:10