Abstracts - PAGE Meeting (Population Approach Group Europe)

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Abstracts (27)

I-01Andrijana Radivojevic

Enhancing population PK modeling efficiency using an integrated workflow

Wednesday 10:05-11:40

I-04

Constructing the disease trajectory of CDR-SOB in Alzheimer’s disease progression modelling

Wednesday 10:05-11:40

I-07Alberto Russu

Second-order indirect response modelling of complex biomarker dynamics

Wednesday 10:05-11:40

I-19Alexander Solms

Translating physiologically based Parameterization and Inter-Individual Variability into the Analysis of Population Pharmacokinetics

Wednesday 10:05-11:40

I-22

Title: Rapid Repeat Dosing of Zolpidem – Apparent Kinetic Change Between Doses

Wednesday 10:05-11:40

I-29Elin Svensson

Individualization of fixed-dose combination (FDC) regimens – methodology and application to pediatric tuberculosis

Wednesday 10:05-11:40

I-31Maciej Swat

PharmML – An Exchange Standard for Models in Pharmacometrics

Wednesday 10:05-11:40

I-51Max von Kleist

Systems Pharmacology of Chain-Terminating Nucleoside Analogs

Wednesday 10:05-11:40

II-04Thomas Dumortier

Using a model-based approach to address FDA’s midcycle review concerns by demonstrating the contribution of everolimus to the efficacy of its combination with low exposure tacrolimus in liver transplantation

Wednesday 14:50-16:20

II-12Nicolas Frances

A semi-physiologic mathematical model describing pharmacokinetic profile of an IgG monoclonal antibody mAbX after IV and SC administration in human FcRn transgenic mice.

Wednesday 14:50-16:20

II-14

A Novel PBPK Approach for mAbs and its Implications in the Interpretation of Classical Compartment Models

Wednesday 14:50-16:20

II-22Ekaterina Gibiansky

Immunogenicity in PK of Monoclonal Antibodies: Detection and Unbiased Estimation of Model Parameters

Wednesday 14:50-16:20

II-23Leonid Gibiansky

Monoclonal Antibody-Drug Conjugates (ADC): Simplification of Equations and Model-Independent Assessment of Deconjugation Rate

Wednesday 14:50-16:20

II-29Ignacio Gonzalez-Garcia

Simultaneous Modelling Of Fexofenadine In In Vitro Cell Culture And In Situ Experiments

Wednesday 14:50-16:20

II-30Sathej Gopalakrishnan

Towards assessing therapy failure in HIV disease: estimating in vivo fitness characteristics of viral mutants by an integrated statistical-mechanistic approach

Wednesday 14:50-16:20

II-47Alvaro Janda

Application of optimal control methods to achieve multiple therapeutic objectives: Optimization of drug delivery in a mechanistic PK/PD system

Wednesday 14:50-16:20

II-60Ron Keizer

cPirana: command-line user interface for NONMEM and PsN

Wednesday 14:50-16:20

II-62Gilbert Koch

Solution and implementation of distributed lifespan models

Wednesday 14:50-16:20

III-03Elke Krekels

Item response theory for the analysis of the placebo effect in Phase 3 studies of schizophrenia

Thursday 10:05-11:35

III-13Joanna Lewis

A homeostatic model for CD4 count recovery in HIV-infected children

Thursday 10:05-11:35

III-48Lisa O'Brien

Implementation of a Global NONMEM Modeling Environment

Thursday 10:05-11:35

IV-25Karl Brendel

How to deal properly with change-point model in NONMEM?

Thursday 14:55-16:20

IV-26

Predicting Torsades de Pointes risk from data generated via high-throughput screening

Thursday 14:55-16:20

IV-49Teresa Collins

Performance of Sequential methods under Pre-clinical Study Conditions

Thursday 14:55-16:20

IV-54Zeinab Daher Abdi

Analysis of the relationship between Mycophenolic acid (MPA) exposure and anemia using three approaches: logistic regression based on Generalized Linear Mixed Models (GLMM) or on Generalized Estimating Equations (GEE) and Markov mixed-effects model.

Thursday 14:55-16:20

IV-61Cheikh Diack

An indirect response model with modulated input rate to characterize the dynamics of Aβ-40 in cerebrospinal fluid

Thursday 14:55-16:20

IV-63

Using Bayesian-PBPK Modeling for Assessment of Inter-Individual Variability and Subgroup Stratification

Thursday 14:55-16:20