Abstracts - PAGE Meeting (Population Approach Group Europe)

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Abstracts (29)

A-05Alexander Staab

In Memoriam Hans Schaefer

Wednesday 08:55-09:00

A-06Joachim Grevel

Panel Discussion: Modelling and Simulation and the Regulatory Process

Wednesday 09:00-10:15

A-08Bruno Bieth

Model-based analyses for pivotal decisions, with an application to equivalence testing for biosimilars

Wednesday 11:45-12:05

A-09Sylvain Goutelle

A unified in vivo modeling approach for quantitative prediction of the impact of gene polymorphism and drug interactions on drug exposure

Wednesday 12:05-12:25

A-10France Mentré

Launch of the new journal ‘CPT: Pharmacometrics & Systems Pharmacology’

Wednesday 12:25-12:30

A-12Kyungsoo Park

The World Conference on Pharmacometrics (WCoP)

Wednesday 12:35-12:40

A-14

The neurobiology of placebos

Wednesday 14:05-14:55

A-15Jakob Ribbing

Literature Model for FEV1 in COPD Trials – Separating the Dynamic Components of Placebo Effect, Disease Progression and Interacting Drug Effects

Wednesday 14:55-15:15

A-17Thomas Eissing

A physiologically-based PK/PD model to capture population variability for diabetes research and automatic blood glucose control

Wednesday 16:45-17:05

A-18Maria Kjellsson

Predicting late-phase outcome from early-phase findings using a Model-Based Approach – Application to Type 2 Diabetes Mellitus

Wednesday 17:05-17:25

A-19Franziska Schädeli Stark

Semi-physiologic population PKPD model characterizing the effect of bitopertin (RG1678) glycine reuptake inhibitor on hemoglobin turnover in humans

Wednesday 17:25-17:45

A-20James Yates

Applying mechanistic pharmacokinetic-pharmacodynamic models (PKPD) to describe the growth and inhibition of xenograft tumours in rats and mice by targeted anti-cancer agents.

Thursday 08:45-09:05

A-21Ben-Fillippo Krippendorff

Relationship between the dose of therapeutic antibodies and the inhibition of cytoplasmic and nuclear growth factor signalling

Thursday 09:05-09:25

A-22Mélanie Wilbaux

Population K-PD joint modeling of tumor size and CA 125 kinetics after chemotherapy in relapsed ovarian cancer (ROC) patients

Thursday 09:25-09:45

A-23Ekaterina Gibiansky

PK/PD modeling and optimization of eltrombopag dose and regimen for treatment of chemotherapy-induced thrombocytopenia (CIT) in cancer patients

Thursday 09:45-10:05

A-25Thomas Dorlo

Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive cover after use of miltefosine for the treatment of visceral leishmaniasis

Thursday 11:35-12:00

A-26Sebastian Ueckert

Application of Item Response Theory to ADAS-cog Scores Modelling in Alzheimer’s Disease

Thursday 12:00-12:25

A-29Mats Karlsson

Introduction to Markov modelling

Thursday 14:00-14:40

A-30Oliver Ackaert

A hidden Markov model to assess drug-induced sleep fragmentation

Thursday 14:40-15:00

A-32

Novel Hybrid Artificial Neural Network-Nonlinear Mixed Effect Model Modeling Approach for Population Data Analysis in Model-based Drug Development

Thursday 16:30-16:50

A-33William Denney

N-dimensional Likelihood Profiling: An Efficient Alternative to Bootstrap

Thursday 16:50-17:10

A-34Gilbert Koch

Modeling of delayed phenomena in PKPD by delay differential equations of lifespan type

Thursday 17:10-17:30

A-36Aris Dokoumetzidis

Lumping of compartments

Friday 09:00-09:35

A-37Jin Jin

Model-Based Meta-Analysis for the Efficacy and Safety of Paclitaxel in Cancer Patients

Friday 09:35-09:55

A-38Yasunori Aoki

A practical algorithm for practical parameter identifiability analysis

Friday 09:55-10:15

A-41Anne-Gaelle Dosne

A strategy for residual error modeling incorporating both scedasticity of variance and distribution shape

Friday 10:55-11:15

A-42Ron Keizer

Extended NPDE diagnostics for the between-subject variability and residual error model

Friday 11:15-11:35

A-43Camille Vong

Handling Below Limit of Quantification Data in Optimal Trial Design

Friday 11:35-11:55

A-44France Mentré

Survey on the current use of optimal design approaches and the developments needed in adaptive optimal design for model based analysis performed amongst DDMoRe’s EFPIA members

Friday 11:55-12:15