Abstracts - PAGE Meeting (Population Approach Group Europe)

Abstracts (25)

I-15Peiming Ma

Organization of Target-Mediated Disposition (TMD) Models including Michaelis-Menten (MM), rapid-binding (RB), and quasi-steady-state (Qss) models

Wednesday 10:15-11:45

I-20Eleonora Marostica

Second order Markov modelling of HAMD responses in depression trials

Wednesday 10:15-11:45

I-26Sven Mensing

Evaluation of the long-term decline of platelets following Navitoclax (ABT-263) administration in Cancer Patients with a semi-physiological pharmacodynamic model

Wednesday 10:15-11:45

I-33Michael Neely

Non-Parametric Bayesian Fitting: A Novel Approach to Population Pharmacokinetic Modeling

Wednesday 10:15-11:45

I-41Kayode Ogungbenro

A semi-mechanistic gastric emptying model for double peaks in pharmacokinetics using LDOPA data

Wednesday 10:15-11:45

I-55Arnaud Quelin

How Anti-cancer Targeted Therapies Used in Combination Interact? Analysis with a Semi-mechanistic Model of Minimal Signalling Networks

Wednesday 10:15-11:45

I-60Nikita Rodichenko

Multimodal Physiologically-Based Modelling and Analysis of Kinetics of Drug-Delivery with Modular Nanotransporters (MNT)

Wednesday 10:15-11:45

I-67Alberto Russu

A new, second-order indirect model of depression time course

Wednesday 10:15-11:45

II-03Mark Sale

Identification of optimal NONMEM models using a multi-objective genetic algorithm.

Wednesday 15:10-16:40

II-11

Three case studies of pharmacokinetic model building using a multi-objective genetic algorithm

Wednesday 15:10-16:40

II-22Alexander Staab

A Model-based Meta-analysis Comparison of the Effects of Linagliptin and Sitagliptin on HbA1c Levels in Patients with Type 2 Diabetes Mellitus

Wednesday 15:10-16:40

II-45Eline van Maanen

A step-wise analysis of multiple biomarkers drives the development of a Semi-Mechanistic Comprehensive Model. Application to modulation of Amyloid-β.

Wednesday 15:10-16:40

II-66Kirill Zhudenkov

Application of the SBTOOLBOX2 in drug discovery and development

Wednesday 15:10-16:40

III-22Michael Block

Physiological modeling of inter-individual variability: Combining PBPK modeling and Markov-Chain-Monte-Carlo approaches

Thursday 10:05-11:35

III-27Marion Bouillon-Pichault

Modeling of pain scores from a flexible titration study using an ordered categorical approaches

Thursday 10:05-11:35

III-28

Predicting in vivo drug response and synergistic combinations from three-dimensional tumour cell cultures

Thursday 10:05-11:35

III-42Karina Blei

Development and evaluation of dynamical whole body Physiologically-based Models of the Circulation and the Renin-Angiotensin-Aldosterone system

Thursday 10:05-11:35

III-47Zeinab Daher Abdi

Joint model for longitudinal exposure to mycophenolic acid and rejection survival data in the first year after renal transplantation

Thursday 10:05-11:35

III-51Giuseppe De Nicolao

PCA-based modelling in antidepressant trials: a pre-mechanistic approach

Thursday 10:05-11:35

III-52Ivan Demin

Posterior predictive check to assess similarity of systemic exposure profiles of an inhaled drug product pre- and post- manufacturing modification.

Thursday 10:05-11:35

III-58Pinky Dua

A Systems Pharmacology model of the nerve growth factor (NGF) pathway to aid drug discovery and development

Thursday 10:05-11:35

III-59Vivek Dua

Multi-objective Optimal Control of Non-Viral Gene Delivery

Thursday 10:05-11:35

IV-19Linus Görlitz

Physiological modeling of interindividual variability: PBPK-NLME vs. compartimental modeling

Thursday 15:00-16:30

IV-24Joachim Grevel

Response type modelling and clinical trial simulation.

Thursday 15:00-16:30

IV-45Alvaro Janda

Optimization of pharmacokinetics and pharmacodynamics profiles by optimal control methods. Application to a triptorelin-testosterone PD model.

Thursday 15:00-16:30