Abstracts - PAGE Meeting (Population Approach Group Europe)

Abstracts (30)

B-01Pascal Girard

A Semi-mechanistic Model of Lymphocyte Dynamics in Patients with Multiple Sclerosis Treated with Cladribine Tablets

Wednesday 09:00-09:20

B-06Mats Karlsson

Population Pharmacodynamics of Cladribine Tablets Therapy in Patients with Multiple Sclerosis: Relationship between Magnetic Resonance Imaging and Clinical Outcomes

Wednesday 09:20-09:40

B-07Bambang Adiwijaya

An integrated, mechanistic model of viral eradication and its clinical applications in treatment regimens with direct-acting antivirals for chronic hepatitis C

Wednesday 09:40-10:00

B-08Lutz Harnisch

Presentation of DDMoRe

Wednesday 10:00-10:15

B-10Nick Holford

A tutorial on time to event analysis for mixed effect modellers

Wednesday 11:45-12:45

B-12Chuanpu Hu

Informative Dropout and Visual Predictive Check of Exposure-Response Modeling of Ordered Categorical Data

Wednesday 14:15-14:35

B-13

Novel GPU-based Parallelized Qausi-random Parametric Expectation-Maximization (QRPEM) Estimation Method for Population Data Analysis

Wednesday 14:35-14:55

B-15

Covariate Modelling in Aggregate Data Meta Analysis: A Simulation Study Evaluating Performance of Model Linearization

Wednesday 16:10-16:30

B-16Marc Gastonguay

Full Covariate Models as an Alternative to Methods Relying on Statistical Significance for Inferences about Covariate Effects: A Review of Methodology and 42 Case Studies.

Wednesday 16:30-16:50

B-17

How to analyse multiple ordinal scores in a clinical trial? Multivariate vs. univariate analysis.

Wednesday 16:50-17:10

B-18Julie Bertrand

Some Alternatives to Likelihood ratio and Wald Tests for Pharmacogenetic studies using nonlinear mixed effect models.

Wednesday 17:10-17:30

C-01Abhishek Gulati

Linking in silico and in vitro experiments to identify and evaluate a biomarker for enoxaparin activity

Thursday 08:30-08:55

C-20

Pharmacokinetic-pharmacodynamic-pharmacoeconomic analysis of rituximab for follicular lymphoma

Thursday 08:55-09:20

C-21Elodie Plan

Modelling Techniques Handling Dynamic Pain Scores Characteristics

Thursday 09:20-09:45

C-24Malcolm Rowland

Physiologically based pharmacokinetics: Advancing the clinical dimension

Thursday 11:05-11:55

C-25Ashley Strougo

Scaling pharmacokinetics to estimate the “first dose in children”: comparing allometric scaling and PBPK

Thursday 11:55-12:15

C-27Benjamin Ribba

Evaluation of the antitumor effect of PCV chemotherapy on low-grade gliomas patients with a longitudinal tumor growth inhibition model

Thursday 13:45-14:05

C-28Emma Hansson

PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3 and sKIT as Biomarkers of Tumor Response and Overall Survival Following Sunitinib Treatment in GIST

Thursday 14:05-14:25

C-29Ines Paule

Individual Prediction-Based Dose Adaptation Of Capecitabine: In Silico Comparison With The Standard Method, Impact On Limiting Toxicity and On Antitimour Efficacy

Thursday 14:25-14:45

C-30Coen van Hasselt

Optimizing monitoring strategies of trastuzumab induced cardiotoxicity: Development and application of a population pharmacodynamic model quantifying trastuzumab induced changes in cardiac function

Thursday 14:45-15:05

C-32Lee Kien Foo

Cost minimization of a phase II clinical study

Thursday 16:20-16:40

C-33Sebastian Ueckert

Explicit Optimization of Clinical Trials for Statistical Power

Thursday 16:40-17:00

C-34Peter Gennemark

Optimal design in population kinetic experiments by set-valued methods

Thursday 17:00-17:20

D-01Leonid Gibiansky

Modeling of Drugs with Target-Mediated Disposition

Friday 09:00-09:40

D-37Stefaan Rossenu

Population Pharmacokinetic/Pharmacodynamic Modeling of a New Antithrombotic Drug, The Nanobody® ALX-0081

Friday 09:40-10:00

D-38Angelica Quartino

An integrated G-CSF-myelosuppression model characterizing the target mediated disposition of endogenous G-CSF in breast cancer patients following chemotherapy

Friday 10:00-10:20

D-42Stephan Schmidt

Coping with Time Scales in Disease Systems Analysis: Application to Bone Remodelling

Friday 11:10-11:30

D-43Elba Romero

Coupling complex mechanistic PK/PD modelling with dynamic system analysis to obtain relevant clinical/biological insights. Application to gonadotropin hormone release agonist

Friday 11:30-11:50

D-44Wojciech Krzyzanski

Solving Delay Differential Equations in S-ADAPT by Method of Steps

Friday 11:50-12:10

D-45S. Y. Amy Cheung

Structural identifiability of parallel pharmacokinetic experiments as constrained systems

Friday 12:10-12:30