Abstracts - PAGE Meeting (Population Approach Group Europe)

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Abstracts (37)

I-11Paul Baverel

A novel covariate search method intended for PKPD models with nonparametric parameter distributions

Wednesday 10:15-11:45

I-13Benoît Beck

From the Experimental Model Settings to the Physical System for Interpretable Decision Making

Wednesday 10:15-11:45

I-17Julie Bertrand

Multiple SNP analysis with HyperLasso in Pharmacogenetic Studies using Nonlinear Mixed Effects Models

Wednesday 10:15-11:45

I-18Bruno Bieth

Using a Systems Biology Approach to Explore Clinical Diversity and Investigate Mechanism of Drug Action: Example of the RAAS System in Hypertension

Wednesday 10:15-11:45

I-19Roberto Bizzotto

Drug Effects on Sleep Data from a 28-Day Clinical Study in Insomniac Patients: Covariate Analysis Using a Multinomial Mixed-Effect Markov-Chain Model

Wednesday 10:15-11:45

I-20Marcus Björnsson

Performance of non-linear mixed effects models with and without taking informative dropout into account

Wednesday 10:15-11:45

I-25

A Negative feedback model for a mechanism based description of longitudinal observations: application for bone turnover biomarkers.

Wednesday 10:15-11:45

I-26Marion Bouillon-Pichault

Modeling Pain score in clinical trials using a joint survival-longitudinal mixed model with a Beta distribution in presence of missing values not occurring at random.

Wednesday 10:15-11:45

I-31Anne Brochot

Specifying Models with Time Dependent Pharmacokinetic Parameters in NONMEM

Wednesday 10:15-11:45

I-33Vincent Buchheit

Efficient quality review for modeling input dataset

Wednesday 10:15-11:45

I-42Marylore Chenel

BSA-adjusted dose? An old method to fight old bias

Wednesday 10:15-11:45

I-43S. Y. Amy Cheung

Structural identifiability of parallel pharmacokinetic experiments as constrained systems

Wednesday 10:15-11:45

I-52Emmanuelle Comets

A comparison of bootstrap approaches for estimating standard errors of parameters in linear mixed effects models

Wednesday 10:15-11:45

I-53

Utilising prior literature population models to inform clinical practice – a dosing regimen for immediate N-acetyl cysteine treatment of paracetamol overdose

Wednesday 10:15-11:45

I-55

Maturation of GFR in preterm and term neonates reflected by clearance of different antibiotics

Wednesday 10:15-11:45

I-58Maud Delattre

Pharmacokinetics and stochastic differential equations : model and methodology.

Wednesday 10:15-11:45

I-64Aris Dokoumetzidis

Numerical solution of nonlinear fractional compartmental systems

Wednesday 10:15-11:45

I-65Aris Dokoumetzidis

Multiple dosing for linear fractional pharmacokinetic systems

Wednesday 10:15-11:45

II-13Axel Facius

Modelling and Simulation based Techniques to support Trial Design and Submission of Daxas

Wednesday 14:55-16:10

II-19Christina Friedrich

Comparison of Statistical and Physiological Modeling Methods Using Examples in Drug Discovery and Development

Wednesday 14:55-16:10

II-47Vijay Ivaturi

Selection Bias in Pre-Specified Covariate Models

Wednesday 14:55-16:10

II-53Åsa Kragh

Comparison of methods for handling missing covariate data

Wednesday 14:55-16:10

II-57Takayuki Katsube

Evaluation of Stepwise Covariate Model Building Combined with Cross-Validation

Wednesday 14:55-16:10

II-58Ron Keizer

The bootstrap of Stepwise Covariate Modeling using linear approximations

Wednesday 14:55-16:10

II-62Akash Khandelwal

Influence of Correlated Covariates on Predictive Performance for Different Models

Wednesday 14:55-16:10

III-11Natacha Lenuzza

Development of a PK library of parent drug/metabolite integrated models

Thursday 09:50-11:05

III-18Eleonora Marostica

Population state-space modelling of patient responses in antidepressant studies

Thursday 09:50-11:05

III-19Hafedh Marouani

Kinetic nomograms assist individualization of drug regimens

Thursday 09:50-11:05

III-23Christophe Meille

PK/PD Model of skin toxicity in animal reported as binary outcome

Thursday 09:50-11:05

III-60Klaas Prins

Modeling urge urinary incontinence data acknowledging non-Poisson dispersion of counts within individual provides a major model fit improvement.

Thursday 09:50-11:05

III-61Klaas Prins

Use of a generalized poisson model to describe micturition frequency in patients with overactive bladder disease.

Thursday 09:50-11:05

IV-01Alberto Russu

Integration of response, tolerability and dropout in flexible-dose trials: a case study in depression

Thursday 15:05-16:20

IV-14Doerthe Steller

Extension of Continuous-Time PK/PD Markov Models to Published Count Data

Thursday 15:05-16:20

IV-23Nadia Terranova

A non parametric population approach for selecting biomarkers of a drug action

Thursday 15:05-16:20

IV-25Michel Tod

A meta-analysis regression model for quantitative prediction of the impact of polymorphism on drug exposure

Thursday 15:05-16:20

IV-29

Evaluating Bootstrap Methods in Nonlinear Mixed Effect Models (NMEM) Using a PK Model

Thursday 15:05-16:20

IV-48Thomas Wendl

Modeling of renal failure, dialysis, inhalation and mechanical ventilation: Development of a whole-body physiologically-based pharmacokinetic (PBPK) model for ICU patients with and without renal failure receiving inhalatively administered Amikacin via a tracheal tube.

Thursday 15:05-16:20