Abstracts - PAGE Meeting (Population Approach Group Europe)

Abstracts (26)

Ines Paule (1), Hind Sassi (2), Anoosha Habibi (3), Dora Bachir (3), Frédéric Galactéros (3), Pascal Girard (1), Anne Hulin (2), Michel Tod (1, 4)

Population Pharmacokinetics and Pharmacodynamics of Hydroxyurea in Sickle Cell Anemia Patients, In Silico Comparison of Two Dosing Regimens

Jason H. Williams (1), Bhuvaneswari Jayaraman (1), Richard S. Finkel (2), Jeffrey S. Barrett (1)

Bayesian Network Approach to Modeling Spinal Muscular Atrophy Populations

D.S. Bordin, T.S. Kozhurina, S.Yu. Silvestrova, V.N. Drozdov, E.R. Valitova, A.A. Masharova, A.V. Petrakov

Relating Pharmacokinetics and Pharmacodynamics of Proton Pomp Inhibitors (PPIs) to Clinical Performance in Patients with Gastroesophageal Reflux Disease (GERD)

Andreas Kuttler (1), Thomas Dimke (1), Ramprasad Ramakrishna (2), Gabriel Helmlinger (2), Anne Ruehl (2), Marie-Laure Rouzade-Dominguez(2), Gervais Tougas (2), Mark Fox (3), Werner Schwizer (3)

A 3D mechanical model of the gastric esophageal junction: model-based assessment of muscle stretch tension in the gastric smooth muscle with emphasis to reflux disease

Helene Karcher (1), Ken Abrams (2), Alan Slade (2), Olivier Luttringer (1)

Interpreting QT in a Patient Population After Surgical Intervention

Gregory Pinault, Aurelie Gautier, Goonaseelan Pillai, Jean-Louis Steimer, Vincent Buchheit

Quality, Efficiency and Industrialisation Initiatives during the evolution of a dedicated SAS Programming Group

Nicolás J (1), Oltra D (2), Navarro-Fontestad C (2), Nicolás N (3), Ramírez F (4), Alós M (5), Casabo VG (2)

Population pharmacokinetics of Ropivacaine and Bupivacaine after loco-regional administration as anesthetic in hip or knee replacement surgery.

C. van Kesteren1, M.A. Boroujerdi1, A. Roy1, A. Facius2, M. Danhof1, O.E. Della Pasqua1,3

Prediction of drug effects using a longitudinal turnover model for FEV1 in patients with chronic obstructive pulmonary disease (COPD).

KT. Baron, AK. Birnbaum, JC. Cloyd, J. St. Peter, and RC. Brundage

Evaluation of Assumptions in the Clinical Use of the Cockcroft-Gault Equation

I. Locatelli (1), B. Perissutti (2), D Voinovich (2), A. Mrhar (1), I. Grabnar (1)

Population Pharmacokinetic Analysis of Silymarin Bioavailability in Rats

Guangli Ma1, Bo L Olsson2, Johan Rosenborg2, Mats O. Karlsson1

Quantifying Lung Function Progression in Asthma

C. Ambery(1), M. Beerahee(1)

Population PK-PD Modelling of Wheal and Flare Area in a First-Time-in-Human Study

I. Grabnar (1), T. Trdan (1), P. Bohanec Grabar (2), B. Rozman (3), D. Logar (3), M. Tomsic (3), D. Suput (3), L. Peterlin Masic (1), V. Dolzan (2), A. Mrhar (1)

Population Pharmacokinetics of the Active Metabolite of Leflunomide in Patients with Rheumatoid Arthritis

Roger Jelliffe MD1, Alan Schumitzky PhD1,2, David Bayard PhD1,3, Robert Leary1,4, PhD, Alison Thomson PhD5, Andreas Botnen, MS1, Maurice Khayat BS1, Michael Neely MD1

Optimal Stochastic Control Of Drug Dosage Regimens

Flora Tshinanu Musuamba (1), Michel Mourad (2), Vincent Haufroid (3), Roger K. Verbeeck (1) and Pierre Wallemacq (3).

Time of Drug Administration, Genetic Polymorphism and Analytical Method Influence Tacrolimus Pharmacokinetics: A Population Pharmacokinetic Approach

Musuamba F(1), Mourad M(2), Haufroid V(3), Wallemacq P(4), Verbeeck RK(1)

Multivariate and Population Pharmacokinetic Analyses for Tacrolimus Area Under The Concentration-Time Curve Prediction in De Novo Renal Transplant Recipients

P. Johnson (1), S. W. Martin (1), P. Milligan (1), A. Cleeton (2), A. Heatherington (2), A. Crossland (3), S. Haughie (3), J. Lamb (4), N. Tamimi (4) & N.H. Prins (5).

Enhanced quantitative drug development (EQDD) of a selective PDE5 inhibitor for the treatment of benign prostatic hyperplasia (BPH)

Joseph F Standing (1), Marie Sandström (2), Tommy Andersson (2), Kerstin Röhss (2), Mats O Karlsson (1)

Population Pharmacokinetic Modelling of Esomeprazole Nonlinearity

Martin Bergstrand (1), Sandra Visser (2), Catharina Alm (1), Ahmad Al-Saffar (3), Mats O Karlsson (1)

Semi-mechanistic PK/PD modeling of Paracetamol and Sulfapyridine to characterize effects on gastric emptying and small intestinal transit

Jonathan L. French (1), Neal Thomas (2), Sriram Krishnaswami (3), Gary Chan (4)

Safety monitoring of a kidney transplant study using a Bayesian time-to-event model

R.R. Press(1,2), H.H. van Rossum(3), B.A. Ploeger(4,5), J. den Hartigh(1), J. van Pelt(3), H.-J. Guchelaar(1), J.W. de Fijter(2) and M. Danhof(4,5)

Is Calcineurin Activity Useful as a Biomarker to Optimize Cyclosporine A Therapy in Renal Transplant Recipients?

Thaddeus Grasela* (1), Jill Fiedler-Kelly (1), Darcy Hitchcock (1)

Improving the Efficiency and Ensuring the Quality of Data Assembly for Pharmacometric Analysis

N. Snelder (2), T. van Steeg (2), B. Ploeger (2), N. Attkins (1), P. van der Graaf (1)