Abstracts - PAGE Meeting (Population Approach Group Europe)

Abstracts (12)

S. Retout (1, 2), C. Bazzoli (1), E. Comets (1), H. Le Nagard (1), F. Mentré (1, 2)

Population designs evaluation and optimisation in R: the PFIM function and its new features

Ivelina Gueorguieva and Kimberley Jackson

Prospective application of a multivariate population optimal design to determine parent and metabolite pharmacokinetic sampling times in a Phase II study.

Zexun Zhou, Marc Pfister, and Amit Roy

Optimal Sampling Design and Trial Simulation using POPT and NONMEM

Jeffrey S. Barrett, Jeffrey Skolnik, Bhuvana Jayaraman, Dimple Patel, Peter Adamson

Improving Study Design and Conduct Efficiency of Event-Driven Clinical Trials via Discrete Event Simulation: Application to Pediatric Oncology

Kayode Ogungbenro and Leon Aarons

Sample Size Calculations for Repeated Binary Population Pharmacodynamic Experiments

P. Johnson (1), H. Dai (2), S. Neelakantan (2), T. Tensfeldt (2)

Optimal dose & sample-size selection for dose-response studies

Anthe S. Zandvliet (1), Jan H.M. Schellens (2,3), William Copalu (4), Jantien Wanders (4), Mats O. Karlsson (5), Jos H. Beijnen (1,2), Alwin D.R. Huitema (1)

Phase I study design of indisulam: evaluation and optimization

Marylore Chenel1, Kayode Ogungbenro2, François Bouzom1

Comparison of uniresponse and multiresponse approaches of PopDes to optimize sampling times for drug-drug interaction studies: application to a Servier compound.

Marcella Petrone, Stefano Zamuner, Vincenzo Di Iorio, Roger Gunn, Marc Laruelle and Roberto Gomeni

Model-based sequential human PET study design for Optimal PK/RO assessment

M.A. Fabre (2), E. Fuseau (2), P. Cohen, H. Ficheux (1).

Selection of a dosing regimen with WST11 by Monte Carlo simulations, using PK data collected after single IV administration in healthy subjects and population PK modelling.

C. Bazzoli (1), S. Retout (1, 2), F. Mentré (1, 2)

Population design in nonlinear mixed effects multiple responses models: extension of PFIM and evaluation by simulation with NONMEM and MONOLIX

A. Russu (1), M. Neve (2), G. De Nicolao (1), I. Poggesi (2), R. Gomeni (2)

Population methods for dose escalation studies: an MCMC approach