15th PAGE Meeting

Brugge/Bruges - Belgium
14-16 June, 2006

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Abstracts (9)

Gibiansky, Ekaterina (1), Leonid Gibiansky (2)

Model-Based Drug Development: Optimization of AQUAVAN® Injection Dosing for Minimal-to-Moderate Sedation

Kowalski, Kenneth G., Stephen Olson, Ann Remmers

A Modeling and Simulation Case Study: Impact on an Early Clinical Development Program

Viberg, Anders (1), Otto Cars (2), Mats O. Karlsson (1) and Siv Jönsson (3)

Individualization of Cefuroxime Dosage using Pharmacodynamic targets, MIC distributions and Minimization of a Risk Function

Elsherbiny, D.(1), S. Asimus(2), M.O. Karlsson(1), M. Ashton(2), U. S. H. Simonsson(1)

Modeling of the induction of CYP2B6 and CYP2C19 by artemisinin antimalarials

Edginton, A.N.(1), S. Willmann (1), Sevestre, M (2), Kirchheiner, J (3)

Determining the effect of CYP2C9 genotypes on diclofenac metabolism using individualized coupled physiology-based pharmacokinetic modeling

Roy, A. and M. Pfister

Optimizing Dose Selection With Respect to Multiple Safety/Efficacy Endpoints Using Clinical Utility Concepts

Mondick, John T.(1), Leonid Gibiansky (2), Marc R. Gastonguay (2), Gareth J. Veal (3), Jeffrey S. Barrett (1)

Acknowledging Parameter Uncertainty in the Simulation-Based Design of an Actinomycin-D Pharmacokinetic Study in Pediatric Patients with Wilms’ Tumor or Rhabdomyosarcoma

Thomas, F.(1), S Séronie-Vivien(1), F Bouissou(2), M Tafani(2), JP Delord(1), L Gladieff(1), E Chatelut(1)

Cystatin C as a new covariate to predict the renal elimination of drugs

Woltosz, Walter S. and Michael B. Bolger

Simulation of the Nonlinear PK of Gabapentin and Midazolam in Adult and Pediatric Populations