Abstracts - PAGE Meeting (Population Approach Group Europe)

Abstracts (57)

Michael K. Smith(1), Scott Marshall(2), John Huggins(2).

A Bayesian design and analysis for dose-response using informative prior information

Dymphy Huntjens (1), Anne Chain (1), David Spalding (2), Meindert Danhof (1) and Oscar Della Pasqua(1,3)

Population semi-parametric modelling of the pharmacokinetics of rofecoxib in rats

Willem de Winter (1), Teun Post (1), Joost DeJongh (1,2), Richard Urquhardt(3), Ian Moules (3), David Eckland (3) and Meindert Danhof (1,2)

A Mechanistic Disease Progression Model for Type 2 Diabetes Mellitus and Pioglitazone Treatment Effects

Emmanuelle Comets, France Mentré and François Gimenez

Cerebral uptake of mefloquine enantiomers with and without theP-gp inhibitor elacridar (GF1210918) in mice

Sandra A.G. Visser (1), Björn Sällström (1), Tomas Forsberg (2), Svante B. Ross (3), Lambertus A. Peletier (4) and Johan Gabrielsson (1)

Modeling of drug- and system-related changes in body temperature: application to drug-induced hypothermia, long-lasting tolerance development and diurnal variation in body temperature

Jean-Eric Charoin(1), Philippe Jacqmin(2), Ludger Banken(3), Sian Lennon(4) and Karin Jorga(1)

Population Pharmacokinetic Analysis of Trastuzumab (Herceptin) following Long-Term Administration Using Different Regimens.

Maria C. Kjellsson, Mats O. Karlsson

Fitting Proportional Odds model to Ordered Categorical Data using the NLMIXED Procedure

K.C. Carlsson (1), N.O. Hoem (2), T. Glauser (3), A. A. Vinks (4).

Can clinically useful population PK models for carbamazepine in pediatric epilepsy patients be developed based on routine therapeutic drug monitoring (TDM) data?

Marc Lavielle(1) and the Monolix research group(2)

SAEM in MATLAB: an alternative to linearization

Niels Rode Kristensen

A Deconvolution Method for Linear and Nonlinear Systems based on Stochastic Differential Equations

Poggesi I (1), Simeoni M (2), Germani M(1), De Nicolao G(2), Rocchetti M(1)

Population modeling of tumor growth in untreated xenografted mice

E. Tousset (1), C. Reners (1) & B. Vrijens (1-2)

Identifying and minimizing major sources of variability in population pharmacokinetic studies

John C Lukas(1), Martina Samiotaki(2), Maria Kontou(2), Rosario Calvo(3), Panos Macheras(1), Tasos Zografidis(3), Georgios Kyriakides(4)

The cytochrome P450 3AP1 variant genotype shows correlation with the true clearance in a renal transplant population

F. Fiorentini (2), M. Simeoni (1), I. Poggesi (2), G. Westerberg (2), M. Rocchetti (2)

An example of application of the population approach to toxicological studies.

E.Y.L. Blair(1), D.R. Mould(2), S.J. Clarke(3), L.P. Rivory(4), A.J. McLachlan(1)

Pharmacokinetic-Pharmacodynamic Modelling of Raltitrexed in Patients with Advanced Solid Tumours

Hugo Maas, Meindert Danhof, Oscar Della Pasqua

Comparison of sumatriptan and naratriptan using a markov model approach

E Lamont (1), AH Thomson (2,3), M Dawber (2), L Semple (4), E Bell (4), RA Seaton (4)

Population Pharmacokinetics of Teicoplanin in Outpatient Home Parenteral Antibiotic Therapy (OHPAT)

F. Hourcade-Potelleret, C. Weber, B. Fotteler and N. Frey

Population PK Analysis in Sparse Data and Flexible Sampling Time Conditions

A.S. Zandvliet(1,2), A.D.R. Huitema(1,2), M.E. de Jonge(1,2), R. den Hoed(3), R.W. Sparidans(3), V.M. Hendriks(4,7), W. van den Brink(5,7), J.M. van Ree(6,7), J.H. Beijnen(1,2,3)

Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine

C. Ambery (1), L. Aarons (1)

Population Pharmacokinetics and Response of ICL670 a Novel Oral Iron Chelator in Beta-Thalassaemia Patients

O. Sayar(1), L. Bueno(1), M.J. Garrido(1), F. Rombout(2), I.F. Trocóniz(1)

Comparison of different models to describe simultaneously the kinetics of parent drug and metabolites after oral administration.

R. V. Overgaard(1,2), E. N. Jonsson(3), C. W. Tornøe(4), H. Madsen(2)

Non-Linear Mixed Effects Models with Stochastic Differential Equations – Implementation of an Estimation Algorithm

Matthew L. Zierhut(1), Mark C. Peterson(2), Marc R. Gastonguay(3), Steven W. Martin(2), Paolo Vicini(1), Pirow J. Bekker(2), Donna Holloway(2), Philip T. Leese(4)

Development and Evaluation of a Population PK/PD Model for Fc-OPG in Healthy Postmenopausal Women

T. Lehr (1), C. Tillmann (2), A. Staab (2), D. Trommeshauser (2), H.G. Schaefer (2), C. Kloft (1)

Clock time as a control variable for gall bladder emptying in an enterohepatic circulation model

Holger Kraiczi (1), Marianne Frisén (2)

Effect of Uncertainty About Population Parameters on Pharmacodynamics-Based Prediction of Clinical Trial Power – A Method for Sensitivity Analysis

Michael G Dodds(1), Andrew C. Hooker(1) and Paolo Vicini(1)

Robust Population Pharmacokinetic Experiment Design

Michael G Dodds(1), Paolo Vicini(1), Jennifer E Visich(2) and Mark Rogge(2)

A Population PK Model for Recombinant Factor XIII in Congenitally Deficient Subjects

C. Lia Liefaard (1), Bart A. Ploeger (1,2), Carla F.M. Molthoff (3), Ronald Boellaard (3), Adriaan A. Lammertsma (3), Meindert Danhof (1,2), Rob A. Voskuyl (1,4)

Application of Population Pharmacokinetic Analysis for Quantification of in vivo Binding Properties in the Rat Brain by Positron Emission Tomography

Justin J Wilkins (1), Grant Langdon (1), Helen McIlleron (1), Goonaseelan Pillai (2), Peter J Smith (1) and Ulrika SH Simonsson (3)

A population pharmacokinetic-enzyme model for rifampicin autoinduction and bimodal absorption in pulmonary tuberculosis patients

K.H. Liesenfeld, EU. Gräfe-Mody, A. Staab, H.G. Schaefer

Population pharmacokinetics of a new anticoagulant drug in clinical development

V. Piotrovsky(1), G. Kopia(2), G.W. Vetrovec(3), D. Rizik(4), David Snead(2)

Population pharmacokinetic analysis of concentration data after implantation of sirolimus-eluting Bx Velocity stent in patients

Vermeulen, An; Piotrovsky, Vladimir and De Ridder, Filip

Modeling the occurrence of orthostasis using a longitudinal logistic regression model

Pieter Janssen(1,2), Nicolaas H. Prins(2), Pieter J. Peeters(2), Klaas P. Zuideveld(3) and Romain A. Lefebvre(1)

Quantification of 5-HT7 receptor efficacy distribution throughout the canine stomach using the operational model of agonism.

Sylvie Retout, Emmanuelle Comets and France Mentré