Abstracts - PAGE Meeting (Population Approach Group Europe)

Abstracts (42)

Ziad Hussein (1), Maria Pitsiu (1), Oneeb Majid (1), L. Aarons (2), A. Stockis (3) and M. de Longueville (3)

Retrospective Population Pharmacokinetics Of Cetirizine In Infants And Children

Eric Masson, 1, Eliane Fuseau, 2, Valérie Cosson, 2

Efficiency of Using Population Pharmacokinetics to Demonstrate Bioequivalence with Sparse Sampling in Cancer Patients- A Trial Simulation with Etoposide

Vermeulen, An and Piotrovsky, Vladimir

Modelling of the effect of carbamazepine on the pharmacokinetics of risperidone in psychotic patients of different phenotypes

Merle Y.(1), Treluyer JM* (2), Tonnelier S (2), Rey E (2), Pons G (2).

Nonparametric Population Analysis Of Amikacin Pharmacokinetic Data In A Pediatric Population.

L.Claret(1), P.Macheras(2), N.Simon(3), A.Iliadis(4)

The Use Of A Stochastic Model For Data Exhibiting Heterogeneous Pharmacokinetics

L. Nguyen (1), S. Retout (2), F. Mentré (2), P. Variol (1) and C. Puozzo (1)

Population pharmacokinetics of vinflunine from phase I data and evaluation of population sampling designs for further clinical development

Xuejun Chen, Suresh Mallikaarjun, Zhao Wang, Steven L. Bramer

Population PK Modeling of drugs exhibiting less than proportional increases in pharmacokinetics relative to increasing doses

A.A. Yao(a), J.T. Slattery(b,c), G.B. McDonald(c), and P. Vicini(a)

Population pharmacokinetics of cyclophosphamide and its metabolites in hematopoietic stem-cell transplantation patients

P.Baille-Albert (1), O.Petricoul (1), E.Fuseau (1), A.Iliadis (2)

Information indexes for exploratory data analysis in population pharmacokinetics

Sophie Glatt1, Olivier Petricoul1, Ciara Rossier2, Quyen T.X Nguyen2, Alain Munafo2, Timothy Goggin2, Mauro Buraglio2, and Eliane Fuseau1

Pooled PK analysis of Interferon-beta-1a (Rebif), data obtained in healthy subjects and in patients.

Lars Lindbom, Mats O. Karlsson, E. Niclas Jonsson

Symmetry and coverage of confidence intervals for a population PK model.

J.B. Fau * & C. Dubruc *, F. Mentré **.

Population PK/PD modelling of a new MAO-B inhibitor in young and elderly healthy volunteers.

Xiaofeng Wang and Siu-Kei Tin

Population pharmacokinetics model validation using Kinetica

Perdaems Lambert N.(1), Bouzom F.(1), Freidig A.(2), Solbes Marchetti M.N.(1), Jochemsen R.(3), and Walther B.(1)

The Use Of Physiologically Based Pharmacokinetic (PBPK) Model In Drug Development

L. Del Frari, F. Bouzom, B. Walther and R.Jochemsen

Pharmacokinetic Mixed Effects Modelling of S16257 After Oral Administration in the Beagle Dog; Combined Analysis

A. Diot(1,2), C. Laveille(2), N. Frey(2), R. Jochemsen(2) & A. Mallet(1)

Gauss Hermite Quadrature in Population Parameters Estimation. Application to the Detection of Subpopulations

Howard Lee, Hui C. Kimko, Mark Rogge, Diane Wang, Ivan Nestorov and Carl C. Peck

Population pharmacokinetic and pharmacodynamic modeling of etanercept using logistic regression analysis

F.Hourcade-Potelleret *, C. Laveille *, M.Tod ** and R. Jochemsen *

Mixture models : simulation and estimation with NONMEM

D. Martin , N. Frey , C. Laveille , H. Merdjan and R. Jochemsen

Pharmacokinetic mixed effects modelling of a new compound in rat – Combined analysis.

In-Sun Nam, Leon Aarons

The propagation of information in PK modelling: The use of IV information to support the analysis of PK data

G.Würthwein1, T.Klingebiel2, S.Krümpelmann3, M.Metz4, K.Schwenker4, C.Lanvers1, J. Boos1

Population pharmacokinetics of high-dose etoposide in children receiving different conditioning regimens

Jian-Feng Lu and René Bruno

Assessment of the Predictive Performance of a New Population Pharmacokinetic Model For Trastuzumab (Herceptin) and Simulation of Trastuzumab Steady-State Exposure During Long-Term Weekly Dosing.

Sandrine MICALLEF, Thomas J. SMITH, Frédéric Y. BOIS

Modelling of intra-individual and inter-individual variability in 1,3-butadiene metabolism

Liping Zhang

Simultaneous vs. Sequential Estimation in PK/PD Data Analysis

S. Gisbert, I. Gueorguieva, G. Graham, L. Aarons

Incorporating Uncertainty and Variability in the Physiological Parameters of a PBPK Model

I. Gueorguieva, I. Nestorov, M. Rowland

Reducing PBPK Models Using Global Sensitivity Analysis and Benefit/Cost Criterion

Chanu Pascal, Tranchand Brigitte, Robert Jacques

Population pharmacokinetics of epirubicin and its main metabolite epirubicinol using NONMEM

Georges B., Saivin S., Archambaud M., Conil JM., Decun JF., Cougot P., Virenque C., Houin G.

Cefepime Monitoring in ICU Patients Using a Population Pharmacokinetic Approach

Kim Emil Andersen and Malene Højbjerre

A Bayesian Approach to Bergman’s Minimal Model

Ulrika Wählby(1), Alison H. Thomson(2), Peter A. Milligan(3) and Mats O. Karlsson(1)

Handling of time-varying covariates in population model building.

Susanne Bøttcher and Claus Dethlefsen

Bayesian Networks used in PK/PD modelling

Rizo-Manika M, Saivin S, Georges B, Conil JM, Lavit M, Houin G

Validation Of An Amikacin Population Pharmacokinetics Model To Be Used In Intensive Care Unit

Michel Tod

Handling Concentrations Below Quantification Limit in Population

Andreas V. Groth, Mikael S. Thomsen, Morten Colding-Jørgensen & Erik Mosekilde

Discussion of criteria for evaluating the quality of glucose clamp studies

M.J. García1, D. Santos Buelga1,D. Aumente2, P. Gomez2 ,JC.Lukas1

Population pharmacokinetics of long-term methotrexate in children with lymphoblastic leukemia

D. Santos Buelga1, M.J. García1, MJ Otero2, A. Martin Suarez1, A. Dominguez-Gil2, JC.Lukas1

Phenytoin covariate models for Michaelis-Menten pharmacokinetics in adult epileptic patients

C. Csajka(1), C. Marzolini(1), K. Fattinger(2), L.A. Décosterd(1), J. Fellay(3), A. Telenti(3), J. Biollaz(1), T. Buclin(1)

Population Pharmacokinetics and Effects of Efavirenz in HIV Patients

Jakob Ribbing and E. Niclas Jonsson

The Effect of Collinearity on the Selection of Covariates in Population Pharmacokinetic Analysis

Hussain Mulla, Fazal Nabi, Sanjiv Nichani, Richard K Firmin, Graham Lawson, David R Upton

Population Pharmacokinetics of Theophylline during Paediatric Extracorporeal Membrane Oxygenation (ECMO)

Valle M, Riba J, Yritia M, Barbanoj MJ.

Pharmacokinetics of the three main alkaloids present in the South American psychoactive beverage Ayahuasca after oral administration to healthy volunteers

Siv Jönsson and Mats O. Karlsson

Estimating Bias In Parameters For Some NONMEM Models For Ordered Categorical Data

Juan Jose Perez Ruixo(1); Vladimir Piotrovsky(1); Kenneth H. Cowan(2); Louis Weiner (3); Cornelis J.A. Punt (4); Martine Piccart (5).

Population Pharmacokinetic Analysis of Zarnestra Using Data From Phase I Clinical Trials