43 Software product POPKAN; Population pharmacokinetic modelling and analysis

J Wakefield, G Strehlau

Mathematical Applications, CIBA-GEIGY AG, Basel, Switzerland

POPKAN

is a userfriendly PC-based software system enabling pharmacokinetic researchers to apply the population approach to kinetic and dynamic data profiles.

POPKAN

is an expert system. It offers by a point and click-strategy a full Bayesian solution of complex hierarchical models. POPKAN's computational engine contains the complex Markov Chain Monte Carlo Sampling methodology - a statistical method at frontier of science level - but the user does not need to understand this methodology and does not need to become a statistical expert.

POPKAN

presents the analysis results in graphical forms and numerical summeries. All results can be stored and later be reused and/or integrated in SAS or another reporting system.

POPKAN

offers robust analysis methodology and a variety of graphical diagnostics for model validation and outlier detection.

POPKAN

provides pharmacokinetic and pharmacodynamic prediction for individuals and optimal dosing regimens.

POPKAN

offers flexible specification features in form of

Data:

either SAS-files or ASCII.

Application mode:

single or repeated application schemes for IV, INFUSIONS and PO mode.

Kinetic models:

one and two compartment models.

Dynamic models:

linear regression and E-max-models.