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Lewis Sheiner


2010
Berlin, Germany



2009
St. Petersburg, Russia

2008
Marseille, France

2007
København, Denmark

2006
Brugge/Bruges, Belgium
   Program
   Abstracts
   Participants
2005
Pamplona, Spain

2004
Uppsala, Sweden

2003
Verona, Italy

2002
Paris, France

2001
Basel, Switzerland

2000
Salamanca, Spain

1999
Saintes, France

1998
Wuppertal, Germany

1997
Glasgow, Scotland

1996
Sandwich, UK

1995
Frankfurt, Germany

1994
Greenford, UK

1993
Paris, France

1992
Basel, Switzerland


2006
   Brugge/Bruges, Belgium

author

title

date

type

Al Za’abi MA (1), Xiaonian X (2), Donovan T (3), Charles BG (1)

Use of Routine Data for Determination of the Population Pharmacokinetics and Enteral Bioavailability of Phenytoin in Neonates and Infants with Seizures

3/27/2006 4:07:15 AM

Poster: Applications- CNS

Bertrand, Julie, Emmanuelle Comets, France Mentré

Detecting a gene effect in pharmacokinetic models: comparison of different methods

3/31/2006 11:12:35 AM

Poster: Methodology- Other topics

Bogacka, Barbara (1) Maciej Patan (2)

Efficient Sampling Windows for Parameter Estimation in Population Models

3/28/2006 6:36:16 PM

Poster: Methodology- Design

Boström, Emma, Ulrika S. H. Simonsson and Margareta Hammarlund-Udenaes

In vivo blood-brain barrier transport of oxycodone in the rat – active influx and implications for PK/PD

3/28/2006 4:43:23 PM

Poster: Applications- CNS

Brendel, Karl(1,3), Céline Dartois(2,3), Emmanuelle Comets(1), Christian Laveille(4), Annabelle Lemmenuel-Diot(3), Brigitte Tranchand(2,6), Pascal Girard(2,5), Céline Laffont(3), France Mentré(1)

Are population PK/PD models adequately evaluated? An exhaustive survey of the literature between 2002 and 2004

3/31/2006 5:29:30 PM

Oral Presentation: Model Building Session

Prins, K (1), B. Poland (1), V. Nicolas (2), H. Porchet (2), P. Scalfaro (2), R. Bruno (1)

Modeling and Simulation of DEBIO-025 to Support Design of a Dose-Response Monotherapy Study in HIV-1 infected Patients

3/27/2006 12:06:27 PM

Poster: Applications- Anti-infectives

Claret, L. (1), P. Girard (2), K.P. Zuideveld(3), K. Jorga (3), J. Fagerberg (3), R. Bruno (1)

A longitudinal model for tumor size measurements in clinical oncology studies

3/31/2006 3:46:45 PM

Poster: Applications- Oncology

Bulitta, J.(1), T. P. Lodise(2), G. L. Drusano(3), M. Kinzig-Schippers(1), U. Holzgrabe(4), F. Sörgel(1,5)

Bias and Uncertainty of Monte Carlo Simulations with Beta-Lactams

3/29/2006 9:29:24 PM

Poster: Applications- Anti-infectives

Carlsson, Kristin C., Radojka M. Savic, Andrew Hooker, Mats O. Karlsson.

Mixture models in NONMEM - how to find the individual probability of belonging to a specific mixture, and why this can be useful information

3/27/2006 3:57:37 PM

Poster: Methodology- Other topics

Chantel, S.(1,2), P. Martin(1,2), P.Y. Petit (3), D. Massignon(4), X. Dode(1), P. Maire (5), R.W. Jelliffe(6), G. Aulagner(1,2)

Pharmacokinetic variability of the absorption of enoxaparin used subcutaneously for venous thromboembolism prophylaxis

3/30/2006 9:47:16 PM

Poster: Applications- Coagulation

Nekka, Fahima (1,2), Caroline-E. Petit-jetté (1), Jun Li (1,2), Denis Gohore Bi (1), Renée Bergeron (3), Jérome del Castillo (4)

Therapeutic modelling and analysis of random feeding features of feed-administered chlortetracycline

4/11/2006 11:23:34 AM

Poster: Applications- Anti-infectives

Armendariz Y2, Caldes A2 , Colom H1, Gilvernet S2, Peraire C1, Domenech J1, Grinyó JM2, Wilkins J3, Karlsson M3.

Population pharmacokinetics of Valganciclovir in solid organ transplant recipients infected by cytomegalovirus

3/31/2006 6:54:50 PM

Poster: Applications- Anti-infectives

Comets, Emmanuelle(1) and Céline Verstuyft (2)

Analysis of digoxin data using Non-Parametric Maximum Likelihood (NPML)

3/31/2006 5:38:32 PM

Poster: Methodology- Algorithms

Cronier, D. (1,5), E. Grenier (2), M. Lecomte (3), V. Autier (3), B. Ladstetter (4), L. J. Aarons (5), and J.P. Boissel (1)

Modelling of insulin secretion: from beta-cell physiology to sulphonylurea-mediated insulin secretion

3/27/2006 3:35:22 PM

Poster: Applications- Endocrine

Dansirikul, C. H.E. Silber, M.O. Karlsson

Comparison of models for baseline

3/29/2006 7:05:44 PM

Poster: Methodology- Model evaluation

Dartois, C (1)(4), K Brendel (2)(4), E Comets (2), C Laveille (3), C Laffont (4), B Tranchand (1)(5), F Mentré (2), A Lemenuel-Diot (4), and P Girard (1)(6).

How is model building reported for population PK-PD? An exhaustive survey of the literature between 2002 and 2004

3/31/2006 2:19:57 PM

Oral Presentation: Model Building Session

Dehez, Marion(1)(2)(3), Marylore Chenel(1), Roeline Jochemsen(1), Stéphanie Ragot(2)

Population modeling approach of circadian blood pressure variations using ambulatory monitoring in dippers and non dippers

3/31/2006 10:04:26 AM

Poster: Applications- Other topics

GastroPlus

GastroPlus

5/17/2006 12:28:23 PM

Software demonstration

Dodds, M.G. (1), J.E. Visich(1), I. Nestorov(1), R. Overgaard(2), M.C. Rogge(1)

Population pharmacodynamic model of the effects of recombinant human interleukin 21 on platelets in humans

3/31/2006 11:45:11 PM

Poster: Applications- Oncology

Dokoumetzidis, Aris and Leon Aarons

Direct application of Bayes theorem for the combination of population pharmacokinetic analyses.

3/29/2006 6:25:57 PM

Poster: Methodology- Other topics

Duffull, S B (1), G Graham (2), K Mengersen (3)

Bayesian Estimation of Optimal Sampling Times for Pharmacokinetic Models

3/21/2006 11:44:49 PM

Poster: Methodology- Design

Edginton, A.N.(1), S. Willmann (1), Sevestre, M (2), Kirchheiner, J (3)

Determining the effect of CYP2C9 genotypes on diclofenac metabolism using individualized coupled physiology-based pharmacokinetic modeling

3/31/2006 2:05:47 PM

Oral Presentation: Applications

Edginton, A.N. (1), S. Willmann (1), M. Kleine-Besten (2)

Use of a physiology-based whole-body population model to simulate the influence of anthropometric-, clearance-, and physiological-variance on the pharmacokinetics of drugs

3/31/2006 1:59:20 PM

Poster: Methodology- PBPK

Elsherbiny, D.(1), S. Asimus(2), M.O. Karlsson(1), M. Ashton(2), U. S. H. Simonsson(1)

Modeling of the induction of CYP2B6 and CYP2C19 by artemisinin antimalarials

3/15/2006 12:13:39 PM

Oral Presentation: Applications

ICON Development SolutionsTM

Hands-On Demonstration of PDx-Pop® v2.0; Tools for Expediting Population Analysis

5/13/2006 8:49:51 AM

Software demonstration

Friberg, Lena E.(1), An M. Vermeulen(2), Mats O. Karlsson(1)

A mechanism-based pharmacokinetic-pharmacodynamic model of the time-course of prolactin following antipsychotic drug treatment

3/20/2006 8:49:25 PM

Poster: Applications- CNS

Gaynor, Clare (1), Dunne, Adrian (1) and Davis, John (2)

Comparison of conventional In Vitro - In Vivo Correlation methodology with non-linear mixed effects modelling

3/27/2006 1:59:59 PM

Poster: Methodology- Other topics

Gibiansky, Leonid, Marc R. Gastonguay

R/NONMEM Toolbox for Simulation from Posterior Parameter (Uncertainty) Distributions

3/27/2006 10:36:26 PM

Poster: Methodology- Algorithms

Gibiansky, Ekaterina (1), Leonid Gibiansky (2)

Model-Based Drug Development: Optimization of AQUAVAN® Injection Dosing for Minimal-to-Moderate Sedation

3/27/2006 10:58:10 PM

Oral Presentation: Applications

Grasela, Thaddeus(1), Jill Fiedler-Kelly(1), Cynthia Walawander(1), Charles W. Dement(2)

Challenges in the Transition to Model-Based Development

3/2/2006 4:44:37 PM

Oral Presentation

Gupta, M, K Wade, B Jayaraman, J Mondick, JS Barrett

Optimizing Fluconazole Dosing in Preterm Neonates Based on Simulations from Posterior Parameter (Uncertainty) Distributions

3/31/2006 9:20:46 PM

Poster: Applications- Anti-infectives

Guzy, Serge

Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/ Pharmacodynamic (PK/PD) Data

1/14/2006 7:59:24 PM

Oral Presentation: Methodology

Guzy, Serge

The PDX-MC-PEM software

5/5/2006 9:16:43 AM

Software demonstration

Hempel, Georg; Lanvers-Kaminsky, Claudia; Ahlke, Elvira; Müller, Hans-J.; Würthwein, Gudrun; Boos, Joachim

A Population Model Describing the Activity-time Course of Pegylated Asparaginase in Children

3/31/2006 4:10:08 PM

Poster: Applications- Oncology

Hénin, Emilie(1), Klaas P. Zuideveld (2), Céline Dartois (1), Brigitte Tranchand (1,3), Gilles Freyer (1,4), Pascal Girard (1,5)

A KPD Model for ordered categorical data: application to toxicity score in colorectal cancer patients treated with capecitabine

3/9/2006 2:49:46 PM

Oral Presentation: Lewis Sheiner Student Session

Hennig, S. (1,2), Wainwright, CE. (3), Bell, SC. (4), Miller, H. (2) Friberg, LE. (1) and Charles, BG. (1)

Paediatric population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in cystic fibrosis and bone marrow transplant patients

3/30/2006 9:49:16 AM

Poster: Applications- Anti-infectives

Hennig, S. (1,2), Waterhouse T.(1) Wainwright C.(3), Bell S.(4), Miller H. (2), Charles B.(1) and Duffull S.(1)

A D-optimal designed population pharmacokinetic study of itraconazole capsules and solution in adults with cystic fibrosis

1/16/2006 8:24:01 AM

Poster: Methodology- Design

Hing, Jeremy(1), Juan Jose Perez-Ruixo(1), Kim Stuyckens(1), Peter Zannikos(1), Arturo Soto-Matos(2), César Picó(2), Antoine Yver(1) and Andrew Chow(1)

Population PK/PD Modelling & Simulation of Hematological Toxicity of Trabectedin in Cancer Subjects

3/31/2006 9:13:49 PM

Poster: Applications- Oncology

Holford, Nick, Carl Kirkpatrick, Steve Duffull

NONMEM Termination Status is Not an Important Indicator of the Quality of Bootstrap Parameter Estimates

3/31/2006 11:27:23 AM

Poster: Methodology- Model evaluation

Hooker, Andrew, Christine E. Staatz and Mats O. Karlsson.

Conditional weighted residuals, an improved model diagnostic for the FO/FOCE methods.

3/31/2006 2:57:34 PM

Oral Presentation: Stuart Beal Methodology Session

Hutmacher, Matthew M, Sriram Krishnaswami

An extension of the indirect response models to ordered categorical pharmacodynamic data using latent variables

3/31/2006 8:19:10 PM

Poster: Methodology- Other topics

Hutmacher, Matthew M , Anand Vidyashankar, and Debu Mukherjee

Model Selection Using the Minimum Hellinger Distance Criterion (MHDC) with an Introduction to Minimum Hellinger Distance Estimation (MHDE)

3/31/2006 8:14:29 PM

Oral Presentation: Stuart Beal Methodology Session

Jelliffe, R., A Schumitzky, D Bayard, R Leary, M Van Guilder, A Gandhi, M Neely, and A Bustad.

The USC*PACK BigWinPops and MM-USCPACK Software

4/28/2006 3:36:13 AM

Software demonstration

Joerger, M., A.D.R. Huitema, V. D. Doodeman, H. Boot, R. W. Sparidans, J.H. Beijnen, J.H.M. Schellens

Epirubicin pharmacokinetics-pharmacodynamics and metabolic pathway-associated gene polymorphisms: Significant influence of the novel UDP-glucuronosyltransferase 2B7 promoter mutation -66T>C

2/27/2006 11:01:41 AM

Poster: Applications- Other topics

Hamrén, Bengt(1), Elisabeth Björk (1), Mats O. Karlsson (2)

Mechanism-based pharmacokinetic and pharmacodynamic modelling of tesaglitazar in type 2 diabetes patients

3/28/2006 1:23:34 PM

Poster: Applications- Endocrine

Karlsson, Mats O. and Radojka Savić

Overview of oral absorption models and modelling issues

5/16/2006 9:20:10 AM

Oral Presentation

Plock, N.(1), C. Buerger(1), K. Kuester(1), C. Joukhadar(2), S. Kljucar(3), C. Kloft(1,4)

A Population Pharmacokinetic Model for the Simultaneous Description of Linezolid Tissue and Plasma Disposition in Healthy Volunteers and Septic Patients

1/16/2006 1:46:04 PM

Poster: Applications- Anti-infectives

Kowalski, Kenneth G., Stephen Olson, Ann Remmers

A Modeling and Simulation Case Study: Impact on an Early Clinical Development Program

3/20/2006 3:17:11 PM

Oral Presentation: Applications

Kuester, K(1), A. Kovar(2), B. Brockhaus(2), C. Kloft(1,3)

Population Pharmacokinetic Analysis for Matuzumab (EMD 72000) – A Humanised EGFR-Targeted Monoclonal Antibody

3/30/2006 11:13:36 AM

Poster: Applications- Oncology

Landersdorfer, C.(1), C. M. J. Kirkpatrick(2), M. Kinzig-Schippers(1), J. Bulitta(1), U. Holzgrabe(3), F. Sörgel(1,4)

New Insights into the Most Commonly Studied Drug Interaction with Antibiotics: Pharmacokinetic Interaction between Ciprofloxacin, Gemifloxacin and Probenecid at Renal and Non-renal Sites

1/15/2006 4:08:29 AM

Poster: Applications- Anti-infectives

Langdon G (1), Gueorguieva I (2), Aarons L (3), Karlsson MO (1)

Linking preclinical and clinical whole body physiologically-based pharmacokinetic models with prior distributions in NONMEM

3/27/2006 3:15:46 PM

Poster: Methodology- PBPK

Lavielle, Marc (1,2,3) Hector Mesa (1) Julie Bertand (4) Adeline Samson (4) France Mentré (4) and the Monolix group

Analysing population PK/PD data with the MONOLIX software

3/31/2006 6:59:35 AM

Software demonstration

Leary, Robert H. and Dunlavey, Michael

Parallel Processing for Nonlinear Mixed Effects Modeling

3/30/2006 8:37:36 PM

Poster: Methodology- Algorithms

Lehr, T.(1), A. Staab (2), C. Tillmann (2), D.Trommeshauser (2), A. Raschig(2), H.G. Schaefer (2), C. Kloft (1,3)

Population pharmacokinetics of NS2330 and its major metabolite in Alzheimer’s disease patients

3/31/2006 8:24:11 AM

Poster: Applications- CNS

Lehr, T. (1), A. Staab (2), C. Tillmann (2), D. Trommeshauser (2), A. Raschig (2), H.G. Schaefer (2), C. Kloft (1,3)

Efficacy modelling of NS2330 in mild Alzheimer’s disease patients

3/31/2006 8:22:17 AM

Poster: Applications- CNS

Zeumer, D., A. Staab, T. Lehr, C. Tillmann, K.-H. Liesenfeld, H. G. Schaefer

PROPHET - A convenient and efficient environment for the use of NONMEM in a global pharmaceutical company

3/31/2006 10:37:26 AM

Poster: Methodology- Other topics

Lindbom, Lars(1), Justin J Wilkins(1), Nicolas Frey(2), Mats O Karlsson(1), E Niclas Jonsson(1,2)

Evaluating the evaluations: resampling methods for determining model appropriateness in pharmacometric data analysis

3/31/2006 2:07:40 PM

Poster: Methodology- Model evaluation

Lopez-Pintor E (1), Valenzuela B (1), Montesinos A (2), Martín-Villodre A (2), Casabó V.G (2)

Population pharmacokinetics approach for salbutamol sulphate in rats

3/31/2006 1:12:03 PM

Poster: Applications- Other topics

Lovern, Mark R , Ginny Schmith, George Dukes, David McSorley

Using a Placebo Response Model to Optimize Clinical Trial Designs for Irritable Bowel Syndrome (IBS) Therapies

3/30/2006 7:30:41 PM

Poster: Applications- Other topics

Marshall, Scott1, Mike K Smith1, Eugene Cox2,3 and Jaap Mandema2,4

Application of PK/PD modelling in the development eletriptan DR for the treatment of acute migraine and prevention of headache recurrence.

3/31/2006 4:27:31 PM

Poster: Applications- CNS

Matthews, Ivan (1), Smith, Fang Gao (2), Aarons, Leon (1)

Pharmacokinetics of a single bolus of propofol in Chinese children of different ages

3/9/2006 4:53:04 PM

Poster: Applications- CNS

Matthews, Ivan and Aarons, Leon

A population pharmacokinetic model for s-warfarin: application of a mixture model to determine genotype/phenotype.

3/30/2006 4:05:41 PM

Poster: Methodology- Model evaluation

Miller, Raymond , Howard Bockbrader, Sunny Chapel.

Comparision of Pregabalin and Gabapentin Pharmacodynamics in Patients with Refractory Partial Seizures.

3/20/2006 8:55:53 PM

Poster: Applications- CNS

Mills, Richard (1,2), Kayode Ogungbenro (1) & Leon Aarons (1)

Simultaneous fitting of the Minimal Model to IVGTT and Glucose Clamp Data

3/23/2006 12:54:23 PM

Poster: Applications- Endocrine

Mondick, John T.(1), Leonid Gibiansky (2), Marc R. Gastonguay (2), Gareth J. Veal (3), Jeffrey S. Barrett (1)

Acknowledging Parameter Uncertainty in the Simulation-Based Design of an Actinomycin-D Pharmacokinetic Study in Pediatric Patients with Wilms’ Tumor or Rhabdomyosarcoma

3/16/2006 1:35:57 AM

Oral Presentation: Applications

Nalda-Molina, R (1), Bermejo M. (2), Casabó V.G. (2)

A simple physiological-pharmacokinetic model to simulate bioequivalence trials

4/4/2006 9:08:52 PM

Poster: Methodology- Model evaluation

Fernández-Teruel C, Navarro-Fontestad MC, González-Álvarez I, Bermejo M, Casabo VG

Sparse sampling designs: a new method for estimating the complete AUC and its standard error

3/31/2006 6:59:09 PM

Poster: Methodology- Algorithms

Nestorov, I.1, A. Munafo2, O. Papasouliotis2, J. Visich1 and M. Rogge1

Population modeling of the relationship between TACI Ig exposure and biomarker response in patients with rheumatoid arthritis (RA)

3/31/2006 8:04:03 PM

Poster: Applications- Biologicals/vaccines

Nielsen, Elisabet I(1), Uwe Ewald (2), Lena E Friberg (1)

Population Pharmacokinetics of Gentamicin in Preterm and Term Newborn Infants

4/20/2006 3:55:41 PM

Poster: Applications- Anti-infectives

Olofsen, E.

Using the Lasso to simultaneously identify the covariate and variance-covariance structures of nonlinear mixed-effects models

3/31/2006 2:29:48 PM

Poster: Methodology- Algorithms

Ortega, Ignacio , An Vermeulen, Vladimir Piotrovsky

Concentration-response analysis of antipsychotic drug effects using an indirect response model

3/31/2006 2:02:02 PM

Poster: Applications- CNS

Paccaly, A (1), Speth, H (2), Jensen, BK (1), Maas, J (2)

Non-Linear Population Pharmacokinetic Model for Otamixaban in Healthy Male Subjects

3/31/2006 3:34:08 PM

Poster: Applications- Coagulation

Panhard, Xavière and Adeline Samson

Extension of the SAEM algorithm for the estimation of Inter-Occasion Variability: application to the population pharmacokinetics of nelfinavir and its metabolite M8

3/27/2006 10:38:38 AM

Poster: Methodology- Algorithms

Perez Ruixo, Juan Jose

Optimizing the Design of Phase I Studies of Erythropoietin Receptor Agonist Through Mechanism-Based PK/PD Modeling and Simulation

4/3/2006 4:15:38 PM

Poster: Applications- Biologicals/vaccines

Marchand, M. (1), O. Petricoul (1), E. Fuseau (1), D. Bentley (2), D. Critchley (2)

Extrapolation from preclinical PKPD data to clinical response, Application to a new antiepileptic medication (drug X)

3/24/2006 6:44:53 PM

Poster: Applications- CNS

Pihlgren, Pontus, Lars Lindbom, Niclas Jonsson

Transforming a set of office computers to a computing cluster.

4/14/2006 9:11:12 PM

Software demonstration

Post, T.M.(1), J.I. Freijer (1), W. de Winter (1), B.A. Ploeger (1,2)

Accurate Interpretation of the Visual Predictive Check in order to Evaluate Model Performance

3/30/2006 3:31:49 PM

Poster: Methodology- Model evaluation

Mango Solutions

Mango Solutions

5/15/2006 11:45:21 AM

Software demonstration

Quartino, Angelica L., Lena E. Friberg, Mats O. Karlsson

A simultaneous analysis of the time course of leukocytes and neutrophils following docetaxel administration using a semi-mechanistic model

3/31/2006 9:43:18 PM

Poster: Applications- Oncology

Ramón-López A. (1), Nalda-Molina R. (1), Valenzuela B. (1), Pérez Ruixo J.J.(1), Jiménez Torres N.V.(2),

Semi-mechanistic KPD model for haematological toxicity in breast cancer patients receiving high dose of chemotherapy

4/3/2006 9:16:12 PM

Poster: Applications- Oncology

Renard, D.(1b), J. Witcher (1a), Y. Nie (2), F. Vandenhende (1b), A. Kumar (3), J. Miller (1a), J. Tauscher (1a), Y. Zhou (3), D. Wong (3)

Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials

3/24/2006 10:36:03 AM

Oral Presentation: Model Building Session

Dittberner, S.(1), V. Duval (2), A. Staab (2), H. Fuchs (2), M. Tadayyon (2), U. Graefe-Mody (2), H.G. Schaefer (2), U. Jaehde (1)

Pre-Clinical PK/PD Modeling for a Dipeptidyl Peptidase-IV Inhibitor

3/30/2006 10:13:36 PM

Poster: Applications- Endocrine

Retout, Sylvie, Emmanuelle Comets, Hervé Le Nagard and France Mentré

New features for population designs evaluation and optimisation in R: PFIM 2.0 and PFIMOPT 2.0

3/31/2006 4:18:09 PM

Software demonstration

Ribbing, J. (1), J. Nyberg (1), O. Caster (1), E.N. Jonsson (1,2)

The LASSO - A Novel Method for Predictive Covariate Model Building in Nonlinear Mixed Effects Models

3/15/2006 2:12:37 PM

Oral Presentation: Methodology

Rodrigues, C.L. (1) , I. Gueorguieva (2), Marylore Chenel (3), D. A. Berk (4) and L. Aarons (1)

Norfloxacin – a whole body physiologically based pharmacokinetic model

3/30/2006 3:54:28 PM

Poster: Methodology- PBPK

Rostami-Hodjegan, A.

Complications in assessing the hepatic first-pass component of bioavailability

5/18/2006 10:27:15 AM

Oral Presentation

Djebli, Nassim 1, Pierre Marquet1,2, Yann Le Meur1,3, Annick Rousseau1,4

Population pharmacokinetics of sirolimus in adult renal transplant patients and Bayesian estimation of individual systemic exposure

3/30/2006 6:14:31 PM

Poster: Applications- Other topics

Prémaud, A(1), Van Guilder M (2), Armstrong VW (3), Weber LT(3), Ghandi A (2), Oellerich M (3), Tonshoff B (3), Jelliffe R (2), Marquet P (1), Rousseau A (1)

Population pharmacokinetics and Bayesian estimation of mycophenolate mofetil in paediatric renal transplant recipients using a non-parametric approach.

3/31/2006 6:04:21 PM

Poster: Applications- Other topics

Rostami-Hodjegan A, Rowland-Yeo K, Jamei M

Simcyp - a platform for simulation and prediction of in vivo drug disposition in virtual human populations

5/17/2006 11:45:19 PM

Software demonstration

Roy Pierre, Annabelle Lemenuel-Diot, Marylore Chenel

Is it possible to perform equivalent simulations with NONMEM and TS2?

3/31/2006 3:30:50 PM

Poster: Methodology- Other topics

Roy, A. and M. Pfister

Optimizing Dose Selection With Respect to Multiple Safety/Efficacy Endpoints Using Clinical Utility Concepts

3/9/2006 12:47:50 AM

Oral Presentation: Applications

Samson, Adeline (1), Marc Lavielle (2) and France Mentré (1)

The SAEM algorithm for non-linear mixed models with left-censored data and differential systems: application to the joint modeling of HIV viral load and CD4 dynamics under treatment

3/15/2006 12:28:22 PM

Oral Presentation: Lewis Sheiner Student Session

Hussein, Ziad(1), Brigitte Lacroix(2), Maria-Laura Sargentini-Maier(2)

Population pharmacokinetics of the new antiepileptic drug brivaracetam

4/20/2006 5:36:37 PM

Poster: Applications- CNS

Savic, Radojka M. , Maria C. Kjellsson, Mats O. Karlsson

Evaluation of the nonparametric estimation method in NONMEM VI beta

3/15/2006 4:17:22 PM

Oral Presentation: Stuart Beal Methodology Session

Silber, Hanna E., Maria C. Kjellsson and Mats O. Karlsson

The likelihood ratio test appears robust to most residual error model misspecifications

3/28/2006 12:59:03 PM

Poster: Methodology- Model evaluation

Holford, Nick, Goonaseelan (Colin) Pillai, Nitin Kaila, William Collins, Sandip Roy, Serge Cremers, Ulrich Trechsel, Florilene Bouisset, Jean-Louis Steimer

PKPD model for cathepsin K inhibition with balicatib and changes in bone turnover biomarkers, in particular NTx

3/31/2006 7:15:37 PM

Poster: Applications- Endocrine

Holford, Nick, Goonaseelan (Colin) Pillai, Sandip Roy, Andrej Skerjanec, Serge Cremers, William Collins, Jean-Louis Steimer

Population pharmacokinetics of balicatib, a cathepsin K inhibitor

3/31/2006 7:11:38 PM

Poster: Applications- Endocrine

Tajima, Takeshi(1), Akihiro Yokoi (1), Peiming Ma (2), Ryosei Kawai (1)

Population approach to assess the relationship of cyclosporin exposure and renal dysfunction in Japanese patients with rheumatoid arthritis

3/1/2006 6:53:13 AM

Poster: Applications- Other topics

Testart, D.(1), G. Blanc(2), P. Delrat(1), T. Shepard(1)

Development of a tool to simulate intra-individual variability encountered in animals from standard preclinical toxicological study

3/14/2006 10:33:04 AM

Poster: Methodology- Design

Thomas, F.(1), S Séronie-Vivien(1), F Bouissou(2), M Tafani(2), JP Delord(1), L Gladieff(1), E Chatelut(1)

Cystatin C as a new covariate to predict the renal elimination of drugs

2/17/2006 5:05:56 PM

Oral Presentation: Applications

Tousset, E.(1), H. Figueiredo (2),M.P. Schneider(2),O. Bugnon(2), B.Vrijens (1)

Relation between patients’ variable compliance and office blood pressure in treatment-resistant hypertension.

3/31/2006 4:28:09 PM

Poster: Methodology- Other topics

Lindbom, L.(1), K. Tunblad(1), L. McFadyen(2), E.N. Jonsson(1), S. Marshall(2), M. O. Karlsson(1)

The use of clinical irrelevance criteria in covariate model building with application to dofetilide pharmacokinetic data

3/27/2006 10:00:56 PM

Poster: Applications- CVS

Valle M, Grasa E, Yritia M, Romero S,, Barbanoj MJ.

Population Pharmacokinetic-Pharmacodynamic modelling of olanzapine effects on the electroencephalogram in healthy volunteers.

3/31/2006 9:41:59 AM

Poster: Applications- CNS

van Eijkeren, J.C.H. (1), M.J. Zeilmaker (1), C.A. Kan (2), L.A.P. Hoogendoorn (3) and W.A. Traag (3)

Model building and model parameter identification for transfer of dioxin TEQs from feed to eggs.

2/7/2006 8:41:39 AM

Oral Presentation: Model Building Session

van Hest, Reinier1, Teun van Gelder1,2, Arnold Vulto1, Leslie Shaw3, Ron Mathôt1

Pharmacokinetic modeling of plasma protein binding of mycophenolic acid in renal transplant recipients

3/8/2006 10:37:14 AM

Poster: Applications- Other topics

Verbeke, Geert

Mixed models for the analysis of categorical repeated measures

3/9/2006 3:31:45 PM

Tutorial

Viberg, Anders (1), Otto Cars (2), Mats O. Karlsson (1) and Siv Jönsson (3)

Individualization of Cefuroxime Dosage using Pharmacodynamic targets, MIC distributions and Minimization of a Risk Function

3/30/2006 3:43:58 PM

Oral Presentation: Applications

Vicini, Paolo

The Population Approach Identity Crisis: The Search For Innovation In Modeling And Simulation

3/21/2006 2:09:59 PM

Oral Presentation

Vicini, Paolo and the Resource Facility for Population Kinetics (RFPK)

The System for Population Kinetics (SPK)

5/4/2006 8:30:40 AM

Software demonstration

Barrett, Jeffrey S. PhD, FCP1, Kalpana Vijayakumar, MS2, Sriram Krishnaswami, PhD3, Manish Gupta, PhD1, John Mondick, PhD1, Bhuvana Jayaraman, BS1, Arun Muralidharan, BS1, Srinivas Santhanam, MS1 and S. Vijayakumar, PhD2

iClinical: NONMEM Workbench

3/31/2006 7:45:08 PM

Software demonstration

Vis, Peter (1), Vanitha Sekar (2), Erno van Schaick (1) and Richard Hoetelmans (3)

Development and application of a population pharmacokinetic model of TMC114 in healthy volunteers and HIV-1 infected subjects after administration of TMC114 in combination with low dose ritonavir

3/29/2006 12:41:45 PM

Poster: Applications- Anti-infectives

Wallin, Johan E, Friberg Lena E., Karlsson Mats O.

An Adaptive Dosing Tool For Etoposide Using Neutrophil Counts Based on a Semi-Physiological Model

3/29/2006 3:46:14 PM

Poster: Applications- Oncology

Weatherley B., L. McFadyen, P. Milligan

Population Analysis of Maraviroc Phase 1 Noncompartmental Pharmacokinetic Data

4/6/2006 6:39:36 PM

Poster: Methodology- Other topics

Wilkins, Justin J (1), Hooker, Andrew (1), Karlsson, Mats O (1), Jonsson, E Niclas (2)

Xpose – an R-based population pharmacokinetic/pharmacodynamic model-building aid for NONMEM

4/13/2006 2:46:03 PM

Software demonstration

Wilkins, Justin J (1), Karlsson, Mats O (1), Jonsson, E Niclas (2)

Patterns and power for the visual predictive check

4/11/2006 11:36:25 AM

Poster: Methodology- Model evaluation

William Faltaos, D (1), S. Urien (1), V.Morel (2), G. Kaloshi (3), k. Hoang Xuan (3), V.Leblond (2), Philippe Lechat (1).

Population pharmacokinetic study of methotrexate in patient with lymphoid malignancy

2/15/2006 2:23:33 PM

Poster: Applications- Oncology

Willmann, Stefan, Andrea N. Edginton, Walter Schmitt, Marcus Kleine-Besten, and Jennifer B. Dressman

Simulating Oral Absorption with PK-Sim®: Methodology and Application Examples

4/28/2006 5:17:27 PM

Oral Presentation

Willmann, Stefan, Wolfgang Weiss, Andrea N. Edginton

Hands-On Demonstrations of the Physiology-Based Pharmacokinetic Software, PK-Sim®

4/28/2006 5:15:17 PM

Software demonstration

Woltosz, Walter S. and Michael B. Bolger

Simulation of the Nonlinear PK of Gabapentin and Midazolam in Adult and Pediatric Populations

3/31/2006 3:27:10 AM

Oral Presentation: Applications

Yim, Dong-Seok (1), Dong-Gun Lee, Su-Mi Choi, Wan-Shik Shin, Hyon-oh Lah(1)

Population pharmacokinetics of meropenem in febrile neutropenic patients in Korea

2/24/2006 5:24:13 AM

Poster: Applications- Anti-infectives

Zandvliet, Anthe S.(1), Alwin D.R. Huitema (1), William Copalu (2), Yasuhide Yamada (3), Tomohide Tamura (3), Jos H. Beijnen (1,4) , Jan H.M. Schellens (4,5)

Pharmacogenetically guided dosing of the anticancer agent indisulam normalizes the risk of severe hematological toxicity

1/17/2006 2:20:46 PM

Poster: Applications- Oncology

Zandvliet, Anthe S. (1), Wandena S. Siegel-Lakhai (1), Jan H.M. Schellens (2,3), William Copalu (4), Gerard Milano (5), Jos H. Beijnen (1,3), Alwin D.R. Huitema (1)

Semi-mechanistic PK/PD model of indisulam in combination with capecitabine: a time-dependent pharmacokinetic interaction contributes to excessive hematological toxicity

3/8/2006 10:25:15 AM

Oral Presentation: Lewis Sheiner Student Session